The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA

The spliceosomal RNA helicase Brr2 catalyzes unwinding of the U4/U6 snRNA duplex, an essential step for spliceosome catalytic activation. Brr2 is regulated in part by the spliceosomal Prp8 protein by an unknown mechanism. We demonstrate that the RNase H (RH) domain of yeast Prp8 binds U4/U6 small nu...

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Detalhes bibliográficos
Main Authors: Mozaffari-Jovin, Sina, Santos, Karine F., Hsiao, He-Hsuan, Will, Cindy L., Urlaub, Henning, Wahl, Markus C., Lührmann, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490000/
https://ncbi.nlm.nih.gov/pubmed/23124066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.200949.112
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