Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA.

Activation of the spliceosome for splicing catalysis requires the dissociation of U4 snRNA from the U4/U6 snRNA duplex prior to the first step of splicing. We characterize an evolutionarily conserved 15.5 kDa protein of the HeLa [U4/U6.U5] tri-snRNP that binds directly to the 5' stem-loop of U4...

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Hlavní autoři: Nottrott, S, Hartmuth, K, Fabrizio, P, Urlaub, H, Vidovic, I, Ficner, R, Lührmann, R
Médium: Artigo
Jazyk:Inglês
Vydáno: 1999
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171676/
https://ncbi.nlm.nih.gov/pubmed/10545122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.21.6119
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