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Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase
The Brr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA–protein complex (di-snRNP) during spliceosome activation via ATP-driven translocation on the U4 snRNA strand. However, it is unclear how bound proteins influence U4/U6 unwinding, which regions of the U4/U6 duplex the helicase actively unw...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4948317/ https://ncbi.nlm.nih.gov/pubmed/27354531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524616113 |
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