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Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase

The Brr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA–protein complex (di-snRNP) during spliceosome activation via ATP-driven translocation on the U4 snRNA strand. However, it is unclear how bound proteins influence U4/U6 unwinding, which regions of the U4/U6 duplex the helicase actively unw...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Theuser, Matthias, Höbartner, Claudia, Wahl, Markus C., Santos, Karine F.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948317/
https://ncbi.nlm.nih.gov/pubmed/27354531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524616113
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