The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

The Brr2 helicase provides the key remodeling activity for spliceosome catalytic activation, during which it disrupts the U4/U6 di-snRNP (small nuclear RNA protein), and its activity has to be tightly regulated. Brr2 exhibits an unusual architecture, including an ∼500-residue N-terminal region, whos...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Absmeier, Eva, Wollenhaupt, Jan, Mozaffari-Jovin, Sina, Becke, Christian, Lee, Chung-Tien, Preussner, Marco, Heyd, Florian, Urlaub, Henning, Lührmann, Reinhard, Santos, Karine F., Wahl, Markus C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699386/
https://ncbi.nlm.nih.gov/pubmed/26637280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.271528.115
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