Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer

PURPOSE: Lapatinib, a small molecule EGFR/HER2 inhibitor, has limited effect on outgrowth of HER2+ brain metastases in preclinical and clinical trials. We investigated the ability of lapatinib to reach therapeutic concentrations in the CNS following (14)C-lapatinib administration (100 mg/kg p.o. or...

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Main Authors: Taskar, Kunal S., Rudraraju, Vinay, Mittapalli, Rajendar K., Samala, Ramakrishna, R. Thorsheim, Helen, Lockman, Julie, Gril, Brunilde, Hua, Emily, Palmieri, Diane, Polli, Joseph W., Castellino, Stephen, Rubin, Stephen D., Lockman, Paul R., Steeg, Patricia S., Smith, Quentin R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489161/
https://ncbi.nlm.nih.gov/pubmed/22011930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0601-8
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