Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study

BACKGROUND: Breast cancer brain metastases (BCBM) are challenging complications that respond poorly to systemic therapy. The role of the blood–tumor barrier in limiting BCBM drug delivery and efficacy has been debated. Herein, we determined tissue and serum levels of capecitabine, its prodrug metabo...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Morikawa, Aki, Peereboom, David M., Thorsheim, Helen R., Samala, Ramakrishna, Balyan, Rajiv, Murphy, Conleth G., Lockman, Paul R., Simmons, Ahkeem, Weil, Robert J., Tabar, Viviane, Steeg, Patricia S., Smith, Quentin R., Seidman, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288517/
https://ncbi.nlm.nih.gov/pubmed/25015089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou141
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