Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study

BACKGROUND: Breast cancer brain metastases (BCBM) are challenging complications that respond poorly to systemic therapy. The role of the blood–tumor barrier in limiting BCBM drug delivery and efficacy has been debated. Herein, we determined tissue and serum levels of capecitabine, its prodrug metabo...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Morikawa, Aki, Peereboom, David M., Thorsheim, Helen R., Samala, Ramakrishna, Balyan, Rajiv, Murphy, Conleth G., Lockman, Paul R., Simmons, Ahkeem, Weil, Robert J., Tabar, Viviane, Steeg, Patricia S., Smith, Quentin R., Seidman, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Clinical Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288517/
https://ncbi.nlm.nih.gov/pubmed/25015089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou141
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