Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study

BACKGROUND: Breast cancer brain metastases (BCBM) are challenging complications that respond poorly to systemic therapy. The role of the blood–tumor barrier in limiting BCBM drug delivery and efficacy has been debated. Herein, we determined tissue and serum levels of capecitabine, its prodrug metabo...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Morikawa, Aki, Peereboom, David M., Thorsheim, Helen R., Samala, Ramakrishna, Balyan, Rajiv, Murphy, Conleth G., Lockman, Paul R., Simmons, Ahkeem, Weil, Robert J., Tabar, Viviane, Steeg, Patricia S., Smith, Quentin R., Seidman, Andrew D.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Clinical Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288517/
https://ncbi.nlm.nih.gov/pubmed/25015089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou141
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