Uptake of ANG1005, a Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

PURPOSE: We evaluated the uptake of angiopep-2 paclitaxel conjugate, ANG1005, into brain and brain metastases of breast cancer in rodents. Most anticancer drugs show poor delivery to brain tumors due to limited transport across the blood-brain barrier (BBB). To overcome this, a 19-amino acid peptide...

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Autores principales: Thomas, Fancy C., Taskar, Kunal, Rudraraju, Vinay, Goda, Satyanarayana, Thorsheim, Helen R., Gaasch, Julie A., Palmieri, Diane, Steeg, Patricia S., Lockman, Paul R., Smith, Quentin R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896053/
https://ncbi.nlm.nih.gov/pubmed/19774344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-009-9964-5
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