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Ligand electronic properties modulate tau filament binding site density
Small molecules that bind tau-bearing neurofibrillary lesions are being sought for premortem diagnosis, staging, and treatment of Alzheimer’s disease and other tauopathic neurodegenerative diseases. The utility of these agents will depend on both their binding affinity and binding site density (B(ma...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488124/ https://ncbi.nlm.nih.gov/pubmed/23072817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2012.09.001 |
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