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Ligand electronic properties modulate tau filament binding site density

Small molecules that bind tau-bearing neurofibrillary lesions are being sought for premortem diagnosis, staging, and treatment of Alzheimer’s disease and other tauopathic neurodegenerative diseases. The utility of these agents will depend on both their binding affinity and binding site density (B(ma...

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Bibliografische gegevens
Hoofdauteurs: Cisek, Katryna, Jensen, Jordan R., Honson, Nicolette S., Schafer, Kelsey N., Cooper, Grace L., Kuret, Jeff
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488124/
https://ncbi.nlm.nih.gov/pubmed/23072817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2012.09.001
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