Optimizing Echinocandin Dosing and Susceptibility Breakpoint Determination via In Vivo Pharmacodynamic Evaluation against Candida glabrata with and without fks Mutations

Echinocandins are a preferred therapy for invasive candidiasis due to their potency and broad spectrum. Resistance, especially in Candida glabrata, is an emerging threat to their use. Pharmacodynamic (PD) studies examining reduced susceptibility secondary to fks mutations in C. glabrata are lacking....

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Главные авторы: Lepak, Alexander, Castanheira, Mariana, Diekema, Daniel, Pfaller, Michael, Andes, David
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2012
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486567/
https://ncbi.nlm.nih.gov/pubmed/22948870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01102-12
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