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Optimizing Echinocandin Dosing and Susceptibility Breakpoint Determination via In Vivo Pharmacodynamic Evaluation against Candida glabrata with and without fks Mutations

Echinocandins are a preferred therapy for invasive candidiasis due to their potency and broad spectrum. Resistance, especially in Candida glabrata, is an emerging threat to their use. Pharmacodynamic (PD) studies examining reduced susceptibility secondary to fks mutations in C. glabrata are lacking....

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Detaylı Bibliyografya
Asıl Yazarlar: Lepak, Alexander, Castanheira, Mariana, Diekema, Daniel, Pfaller, Michael, Andes, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486567/
https://ncbi.nlm.nih.gov/pubmed/22948870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01102-12
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