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Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β-d-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint

Thirteen Candida glabrata strains harboring a range of mutations in hot spot regions of FKS1 and FKS2 were studied. The mutations were linked to an echinocandin reduced susceptibility phenotype. Sequence alignments showed that 11 out of the 13 mutants harbored a mutation in FKS1 or FKS2 not previous...

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Bibliografiske detaljer
Main Authors: Garcia-Effron, Guillermo, Lee, Samuel, Park, Steven, Cleary, John D., Perlin, David S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737881/
https://ncbi.nlm.nih.gov/pubmed/19546367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00443-09
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