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Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β-d-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint

Thirteen Candida glabrata strains harboring a range of mutations in hot spot regions of FKS1 and FKS2 were studied. The mutations were linked to an echinocandin reduced susceptibility phenotype. Sequence alignments showed that 11 out of the 13 mutants harbored a mutation in FKS1 or FKS2 not previous...

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書誌詳細
主要な著者: Garcia-Effron, Guillermo, Lee, Samuel, Park, Steven, Cleary, John D., Perlin, David S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737881/
https://ncbi.nlm.nih.gov/pubmed/19546367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00443-09
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