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Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans: Implications for Interpretive Breakpoints

A detailed kinetic characterization of echinocandin inhibition was performed for mutant 1,3-β-d-glucan synthase enzymes from clinical isolates of Candida albicans with nine different FKS1 mutations resulting in high MICs. Among 14 mutant Fks1p enzymes studied, the kinetic parameters 50% inhibitory c...

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Bibliografski detalji
Glavni autori: Garcia-Effron, Guillermo, Park, Steven, Perlin, David S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612148/
https://ncbi.nlm.nih.gov/pubmed/18955538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01162-08
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