Pyrosequencing To Detect Mutations in FKS1 That Confer Reduced Echinocandin Susceptibility in Candida albicans

Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans. These methods were in complete agreement for 10 of 12 clinical isolates with elevated echinocandin MICs, supporting the potential feasibility...

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Bibliografiska uppgifter
Huvudupphovsmän: Wiederhold, Nathan P., Grabinski, Jodi L., Garcia-Effron, Guillermo, Perlin, David S., Lee, Samuel A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573102/
https://ncbi.nlm.nih.gov/pubmed/18794385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00959-08
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