Optimizing Echinocandin Dosing and Susceptibility Breakpoint Determination via In Vivo Pharmacodynamic Evaluation against Candida glabrata with and without fks Mutations

Echinocandins are a preferred therapy for invasive candidiasis due to their potency and broad spectrum. Resistance, especially in Candida glabrata, is an emerging threat to their use. Pharmacodynamic (PD) studies examining reduced susceptibility secondary to fks mutations in C. glabrata are lacking....

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Détails bibliographiques
Auteurs principaux: Lepak, Alexander, Castanheira, Mariana, Diekema, Daniel, Pfaller, Michael, Andes, David
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486567/
https://ncbi.nlm.nih.gov/pubmed/22948870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01102-12
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