Optimizing Echinocandin Dosing and Susceptibility Breakpoint Determination via In Vivo Pharmacodynamic Evaluation against Candida glabrata with and without fks Mutations

Echinocandins are a preferred therapy for invasive candidiasis due to their potency and broad spectrum. Resistance, especially in Candida glabrata, is an emerging threat to their use. Pharmacodynamic (PD) studies examining reduced susceptibility secondary to fks mutations in C. glabrata are lacking....

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Hlavní autoři: Lepak, Alexander, Castanheira, Mariana, Diekema, Daniel, Pfaller, Michael, Andes, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486567/
https://ncbi.nlm.nih.gov/pubmed/22948870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01102-12
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