Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins

Mammalian prions are thought to consist of misfolded aggregates (protease-resistant isoform of the prion protein [PrP(res)]) of the cellular prion protein (PrP(C)). Transmissible spongiform encephalopathy (TSE) can be induced in animals inoculated with recombinant PrP (rPrP) amyloid fibrils lacking...

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Bibliografski detalji
Glavni autori: Raymond, Gregory J., Race, Brent, Hollister, Jason R., Offerdahl, Danielle K., Moore, Roger A., Kodali, Ravindra, Raymond, Lynne D., Hughson, Andrew G., Rosenke, Rebecca, Long, Dan, Dorward, David W., Baron, Gerald S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Prions
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486332/
https://ncbi.nlm.nih.gov/pubmed/22915801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01353-12
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