Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins

Mammalian prions are thought to consist of misfolded aggregates (protease-resistant isoform of the prion protein [PrP(res)]) of the cellular prion protein (PrP(C)). Transmissible spongiform encephalopathy (TSE) can be induced in animals inoculated with recombinant PrP (rPrP) amyloid fibrils lacking...

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Detalhes bibliográficos
Main Authors: Raymond, Gregory J., Race, Brent, Hollister, Jason R., Offerdahl, Danielle K., Moore, Roger A., Kodali, Ravindra, Raymond, Lynne D., Hughson, Andrew G., Rosenke, Rebecca, Long, Dan, Dorward, David W., Baron, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486332/
https://ncbi.nlm.nih.gov/pubmed/22915801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01353-12
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