Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins

Mammalian prions are thought to consist of misfolded aggregates (protease-resistant isoform of the prion protein [PrP(res)]) of the cellular prion protein (PrP(C)). Transmissible spongiform encephalopathy (TSE) can be induced in animals inoculated with recombinant PrP (rPrP) amyloid fibrils lacking...

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Autori principali: Raymond, Gregory J., Race, Brent, Hollister, Jason R., Offerdahl, Danielle K., Moore, Roger A., Kodali, Ravindra, Raymond, Lynne D., Hughson, Andrew G., Rosenke, Rebecca, Long, Dan, Dorward, David W., Baron, Gerald S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Prions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486332/
https://ncbi.nlm.nih.gov/pubmed/22915801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01353-12
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