N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

Metastasizing tumor cells use matrix metalloproteases, such as the transmembrane collagenase MT1-MMP, together with actin-based protrusions, to break through extracellular matrix barriers and migrate in dense matrix. Here we show that the actin nucleation–promoting protein N-WASP (Neural Wiskott-Ald...

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Main Authors: Yu, Xinzi, Zech, Tobias, McDonald, Laura, Gonzalez, Esther Garcia, Li, Ang, Macpherson, Iain, Schwarz, Juliane P., Spence, Heather, Futó, Kinga, Timpson, Paul, Nixon, Colin, Ma, Yafeng, Anton, Ines M., Visegrády, Balázs, Insall, Robert H., Oien, Karin, Blyth, Karen, Norman, Jim C., Machesky, Laura M.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2012
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483131/
https://ncbi.nlm.nih.gov/pubmed/23091069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201203025
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