Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell cycle progression

During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell cycle progression and cytokinesis. Rac1 null cells migrate markedly less...

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Autors principals: Li, Ang, Ma, Yafeng, Yu, Xinzi, Mort, Richard L., Lindsay, Colin, Stevenson, David, Strathdee, Douglas, Insall, Robert H., Chernoff, Jonathan, Snapper, Scott B., Jackson, Ian J., Larue, Lionel, Sansom, Owen J., Machesky, Laura M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464460/
https://ncbi.nlm.nih.gov/pubmed/21924960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.07.008
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