Activated Mutant NRas(Q61K) Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism

Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation. NRas signals downstream of the major melanocyte tyrosine kinase receptor c-kit and activated NRas results in increased signaling via the...

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Detalhes bibliográficos
Main Authors: Li, Ang, Ma, Yafeng, Jin, Meng, Mason, Susan, Mort, Richard L, Blyth, Karen, Larue, Lionel, Sansom, Owen J, Machesky, Laura M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472562/
https://ncbi.nlm.nih.gov/pubmed/22718121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.186
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