Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4

Hyperpolarization-activated, cyclic nucleotide–sensitive (HCN) channels produce the I(f) and I(h) currents, which are critical for cardiac pacemaking and neuronal excitability, respectively. HCN channels are modulated by cyclic AMP (cAMP), which binds to a conserved cyclic nucleotide–binding domain...

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Main Authors: Liao, Zhandi, Lockhead, Dean, St. Clair, Joshua R., Larson, Eric D., Wilson, Courtney E., Proenza, Catherine
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2012
Teme:
Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483121/
https://ncbi.nlm.nih.gov/pubmed/23109717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210858
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