Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4

Hyperpolarization-activated, cyclic nucleotide–sensitive (HCN) channels produce the I(f) and I(h) currents, which are critical for cardiac pacemaking and neuronal excitability, respectively. HCN channels are modulated by cyclic AMP (cAMP), which binds to a conserved cyclic nucleotide–binding domain...

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Autori principali: Liao, Zhandi, Lockhead, Dean, St. Clair, Joshua R., Larson, Eric D., Wilson, Courtney E., Proenza, Catherine
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
Soggetti:
Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483121/
https://ncbi.nlm.nih.gov/pubmed/23109717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210858
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