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Control of heart rate by cAMP sensitivity of HCN channels
“Pacemaker” f-channels mediating the hyperpolarization-activated nonselective cation current I(f) are directly regulated by cAMP. Accordingly, the activity of f-channels increases when cellular cAMP levels are elevated (e.g., during sympathetic stimulation) and decreases when they are reduced (e.g.,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715536/ https://ncbi.nlm.nih.gov/pubmed/19570998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810332106 |
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