Control of heart rate by cAMP sensitivity of HCN channels

“Pacemaker” f-channels mediating the hyperpolarization-activated nonselective cation current I(f) are directly regulated by cAMP. Accordingly, the activity of f-channels increases when cellular cAMP levels are elevated (e.g., during sympathetic stimulation) and decreases when they are reduced (e.g.,...

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Detaylı Bibliyografya
Asıl Yazarlar: Alig, Jacqueline, Marger, Laurine, Mesirca, Pietro, Ehmke, Heimo, Mangoni, Matteo E., Isbrandt, Dirk
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715536/
https://ncbi.nlm.nih.gov/pubmed/19570998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810332106
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