Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are dually gated channels that are operated by voltage and by neurotransmitters via the cAMP system. cAMP-dependent HCN regulation has been proposed to play a key role in regulating circuit behavior in the thalamus. By analyzing a kn...

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Detalhes bibliográficos
Publicado no:JCI Insight
Principais autores: Hammelmann, Verena, Stieglitz, Marc Sebastian, Hülle, Henrik, Le Meur, Karim, Kass, Jennifer, Brümmer, Manuela, Gruner, Christian, Rötzer, René Dominik, Fenske, Stefanie, Hartmann, Jana, Zott, Benedikt, Lüthi, Anita, Spahn, Saskia, Moser, Markus, Isbrandt, Dirk, Ludwig, Andreas, Konnerth, Arthur, Wahl-Schott, Christian, Biel, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538325/
https://ncbi.nlm.nih.gov/pubmed/31045576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126418
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