Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are dually gated channels that are operated by voltage and by neurotransmitters via the cAMP system. cAMP-dependent HCN regulation has been proposed to play a key role in regulating circuit behavior in the thalamus. By analyzing a kn...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Hammelmann, Verena, Stieglitz, Marc Sebastian, Hülle, Henrik, Le Meur, Karim, Kass, Jennifer, Brümmer, Manuela, Gruner, Christian, Rötzer, René Dominik, Fenske, Stefanie, Hartmann, Jana, Zott, Benedikt, Lüthi, Anita, Spahn, Saskia, Moser, Markus, Isbrandt, Dirk, Ludwig, Andreas, Konnerth, Arthur, Wahl-Schott, Christian, Biel, Martin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538325/
https://ncbi.nlm.nih.gov/pubmed/31045576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126418
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