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PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes
Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN4) channels produce the “funny current,” I(f), which contributes to spontaneous pacemaking in sinoatrial myocytes (SAMs). The C-terminus of HCN channels inhibits voltage-dependent gating, and cAMP binding relieves this “autoinhibition.” We...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989360/ https://ncbi.nlm.nih.gov/pubmed/23756695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.25293 |
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