Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes

Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs). The cardiac “funny current” (If) is among the cAMP-sensitive effectors that drive pacemaking in SAMs. If is produced b...

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Autors principals: Joshua R. St. Clair, Eric D. Larson, Emily J. Sharpe, Zhandi Liao, Catherine Proenza
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2017-08-01
Col·lecció:Journal of Cardiovascular Development and Disease
Matèries:
sinoatrial node
HCN channel
funny current (If)
cardiac pacemaking
cardiomyocyte
cell compartmentalization
phosphodiesterases
cyclic AMP (cAMP)
ion channel
patch clamp
Accés en línia:https://www.mdpi.com/2308-3425/4/3/10
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