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Cyclic AMP reverses the effects of aging on pacemaker activity and I(f) in sinoatrial node myocytes
Aerobic capacity decreases with age, in part because of an age-dependent decline in maximum heart rate (mHR) and a reduction in the intrinsic pacemaker activity of the sinoatrial node of the heart. Isolated sinoatrial node myocytes (SAMs) from aged mice have slower spontaneous action potential (AP)...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5299620/ https://ncbi.nlm.nih.gov/pubmed/28057842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611674 |
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