Bidirectional flow of the funny current (I(f)) during the pacemaking cycle in murine sinoatrial node myocytes

Sinoatrial node myocytes (SAMs) act as cardiac pacemaker cells by firing spontaneous action potentials (APs) that initiate each heartbeat. The funny current (I(f)) is critical for the generation of these spontaneous APs; however, its precise role during the pacemaking cycle remains unresolved. Here,...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Peters, Colin H., Liu, Pin W., Morotti, Stefano, Gantz, Stephanie C., Grandi, Eleonora, Bean, Bruce P., Proenza, Catherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285948/
https://ncbi.nlm.nih.gov/pubmed/34260402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104668118
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