Overall Sulfation of Heparan Sulfate from Pancreatic Islet β-TC3 Cells Increases Maximal Fibril Formation but Does Not Determine Binding to the Amyloidogenic Peptide Islet Amyloid Polypeptide

Islet amyloid, a pathologic feature of type 2 diabetes, contains the islet β-cell peptide islet amyloid polypeptide (IAPP) as its unique amyloidogenic component. Islet amyloid also contains heparan sulfate proteoglycans (HSPGs) that may contribute to amyloid formation by binding IAPP via their hepar...

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Bibliographic Details
Main Authors: Hull, Rebecca L., Peters, Michael J., Perigo, Susan Potter, Chan, Christina K., Wight, Thomas N., Kinsella, Michael G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481315/
https://ncbi.nlm.nih.gov/pubmed/22936797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409847
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