Overall Sulfation of Heparan Sulfate from Pancreatic Islet β-TC3 Cells Increases Maximal Fibril Formation but Does Not Determine Binding to the Amyloidogenic Peptide Islet Amyloid Polypeptide

Islet amyloid, a pathologic feature of type 2 diabetes, contains the islet β-cell peptide islet amyloid polypeptide (IAPP) as its unique amyloidogenic component. Islet amyloid also contains heparan sulfate proteoglycans (HSPGs) that may contribute to amyloid formation by binding IAPP via their hepar...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Hull, Rebecca L., Peters, Michael J., Perigo, Susan Potter, Chan, Christina K., Wight, Thomas N., Kinsella, Michael G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481315/
https://ncbi.nlm.nih.gov/pubmed/22936797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409847
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars