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Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
The eight metabotropic glutamate receptors (mGluRs) are key modulators of synaptic transmission and are considered promising targets for the treatment of various brain disorders. Whereas glutamate acts at a large extracellular domain, allosteric modulators have been identified that bind to the seven...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479612/ https://ncbi.nlm.nih.gov/pubmed/22988116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205838109 |
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