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Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
In multimeric cell-surface receptors, the conformational changes of the extracellular ligand-binding domains (ECDs) associated with receptor activation remain largely unknown. This is the case for the dimeric metabotropic glutamate receptors even though a number of ECD structures have been solved. H...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625292/ https://ncbi.nlm.nih.gov/pubmed/23487753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215615110 |
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