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Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

In multimeric cell-surface receptors, the conformational changes of the extracellular ligand-binding domains (ECDs) associated with receptor activation remain largely unknown. This is the case for the dimeric metabotropic glutamate receptors even though a number of ECD structures have been solved. H...

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Detalhes bibliográficos
Main Authors: Doumazane, Etienne, Scholler, Pauline, Fabre, Ludovic, Zwier, Jurriaan M., Trinquet, Eric, Pin, Jean-Philippe, Rondard, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625292/
https://ncbi.nlm.nih.gov/pubmed/23487753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215615110
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