DEC-205 is a cell surface receptor for CpG oligonucleotides

Synthetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited in clinical vaccine trials. How CpG ODN are captured and delivered to the intracellular receptor TLR9, however, has been elusive. Here we show that DEC-205, a multilectin receptor expressed by a variety of cells,...

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Detalles Bibliográficos
Main Authors: Lahoud, Mireille H., Ahmet, Fatma, Zhang, Jian-Guo, Meuter, Simone, Policheni, Antonia N., Kitsoulis, Susie, Lee, Chin-Nien, O’Keeffe, Meredith, Sullivan, Lucy C., Brooks, Andrew G., Berry, Richard, Rossjohn, Jamie, Mintern, Justine D., Vega-Ramos, Javier, Villadangos, Jose A., Nicola, Nicos A., Nussenzweig, Michel C., Stacey, Katryn J., Shortman, Ken, Heath, William R., Caminschi, Irina
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479608/
https://ncbi.nlm.nih.gov/pubmed/22988114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208796109
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