DEC-205 is a cell surface receptor for CpG oligonucleotides

Synthetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited in clinical vaccine trials. How CpG ODN are captured and delivered to the intracellular receptor TLR9, however, has been elusive. Here we show that DEC-205, a multilectin receptor expressed by a variety of cells,...

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Bibliografiska uppgifter
Huvudupphovsmän: Lahoud, Mireille H., Ahmet, Fatma, Zhang, Jian-Guo, Meuter, Simone, Policheni, Antonia N., Kitsoulis, Susie, Lee, Chin-Nien, O’Keeffe, Meredith, Sullivan, Lucy C., Brooks, Andrew G., Berry, Richard, Rossjohn, Jamie, Mintern, Justine D., Vega-Ramos, Javier, Villadangos, Jose A., Nicola, Nicos A., Nussenzweig, Michel C., Stacey, Katryn J., Shortman, Ken, Heath, William R., Caminschi, Irina
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479608/
https://ncbi.nlm.nih.gov/pubmed/22988114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208796109
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