Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

Improved protein-based vaccines should facilitate the goal of effective vaccines against HIV and other pathogens. With respect to T cells, the efficiency of immunization, or “immunogenicity,” is improved by targeting vaccine proteins to maturing dendritic cells (DCs) within mAbs to DC receptors. Her...

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Detalhes bibliográficos
Main Authors: Idoyaga, Juliana, Lubkin, Ashira, Fiorese, Christopher, Lahoud, Mireille H., Caminschi, Irina, Huang, Yaoxing, Rodriguez, Anthony, Clausen, Björn E., Park, Chae Gyu, Trumpfheller, Christine, Steinman, Ralph M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038758/
https://ncbi.nlm.nih.gov/pubmed/21262813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019547108
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