DEC-205 is a cell surface receptor for CpG oligonucleotides

Synthetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited in clinical vaccine trials. How CpG ODN are captured and delivered to the intracellular receptor TLR9, however, has been elusive. Here we show that DEC-205, a multilectin receptor expressed by a variety of cells,...

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Bibliographische Detailangaben
Hauptverfasser: Lahoud, Mireille H., Ahmet, Fatma, Zhang, Jian-Guo, Meuter, Simone, Policheni, Antonia N., Kitsoulis, Susie, Lee, Chin-Nien, O’Keeffe, Meredith, Sullivan, Lucy C., Brooks, Andrew G., Berry, Richard, Rossjohn, Jamie, Mintern, Justine D., Vega-Ramos, Javier, Villadangos, Jose A., Nicola, Nicos A., Nussenzweig, Michel C., Stacey, Katryn J., Shortman, Ken, Heath, William R., Caminschi, Irina
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479608/
https://ncbi.nlm.nih.gov/pubmed/22988114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208796109
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