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Activation of Neuronal NMDA Receptors Induces Superoxide-Mediated Oxidative Stress in Neighboring Neurons and Astrocytes

Excitotoxic neuronal death is mediated in part by NMDA receptor-induced activation of NOX2, an enzyme that produces superoxide and resultant oxidative stress. It is not known, however, whether the superoxide is generated in the intracellular space, producing oxidative stress in the neurons respondin...

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Detalhes bibliográficos
Main Authors: Reyes, Reno C., Brennan, Angela M., Shen, Yiguo, Baldwin, Ylva, Swanson, Raymond A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478885/
https://ncbi.nlm.nih.gov/pubmed/22973021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1597-12.2012
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