Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling

NMDA-type glutamate receptors (NMDAR) trigger superoxide production by neuronal NADPH oxidase-2 (NOX2), which if sustained leads to cell death. This process involves Ca(2+) influx through NMDAR channels. By contrast, comparable Ca(2+) influx by other routes does not induce NOX2 activation or cell de...

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Publicat a:Sci Rep
Autors principals: Minnella, Angela M., Zhao, Jerry X., Jiang, Xiangning, Jakobsen, Emil, Lu, Fuxin, Wu, Long, El-Benna, Jamel, Gray, John A., Swanson, Raymond A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269523/
https://ncbi.nlm.nih.gov/pubmed/30504838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35725-5
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