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Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling
NMDA-type glutamate receptors (NMDAR) trigger superoxide production by neuronal NADPH oxidase-2 (NOX2), which if sustained leads to cell death. This process involves Ca(2+) influx through NMDAR channels. By contrast, comparable Ca(2+) influx by other routes does not induce NOX2 activation or cell de...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6269523/ https://ncbi.nlm.nih.gov/pubmed/30504838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35725-5 |
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