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Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

Sustained activation of neuronal N-methly D-aspartate (NMDA)-type glutamate receptors leads to excitotoxic cell death in stroke, trauma, and neurodegenerative disorders. Excitotoxic neuronal death results in part from superoxide produced by neuronal NADPH oxidase (NOX2), but how NMDA receptors are c...

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Bibliografiska uppgifter
Huvudupphovsmän: Brennan-Minnella, A M, Shen, Y, Swanson, R A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641334/
https://ncbi.nlm.nih.gov/pubmed/23559014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.111
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