Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

Sustained activation of neuronal N-methly D-aspartate (NMDA)-type glutamate receptors leads to excitotoxic cell death in stroke, trauma, and neurodegenerative disorders. Excitotoxic neuronal death results in part from superoxide produced by neuronal NADPH oxidase (NOX2), but how NMDA receptors are c...

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Bibliografiske detaljer
Main Authors: Brennan-Minnella, A M, Shen, Y, Swanson, R A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641334/
https://ncbi.nlm.nih.gov/pubmed/23559014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.111
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