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Activation of α7 Nicotinic Receptors by Orthosteric and Allosteric Agonists: Influence on Single-Channel Kinetics and Conductance

Nicotinic acetylcholine receptors (nAChRs) are oligomeric transmembrane proteins in which five subunits coassemble to form a central ion channel pore. Conventional agonists, such as acetylcholine (ACh), bind to an orthosteric site, located at subunit interfaces in the extracellular domain. More rece...

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Detaylı Bibliyografya
Asıl Yazarlar: Pałczyńska, Magda M., Jindrichova, Marie, Gibb, Alasdair J., Millar, Neil S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477227/
https://ncbi.nlm.nih.gov/pubmed/22874415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080259
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