Novel C-1 Substituted Cocaine Analogs Unlike Cocaine or Benztropine

Despite a wealth of information on cocaine-like compounds, there is no information on cocaine analogs with substitutions at C-1. Here, we report on (R)-(−)-cocaine analogs with various C-1 substituents: methyl (2), ethyl (3), n-propyl (4), n-pentyl (5), and phenyl (6). Analog 2 was equipotent to coc...

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Bibliografiset tiedot
Päätekijät: Reith, Maarten E. A., Ali, Solav, Hashim, Audrey, Sheikh, Imran S., Theddu, Naresh, Gaddiraju, Narendra V., Mehrotra, Suneet, Schmitt, Kyle C., Murray, Thomas F., Sershen, Henry, Unterwald, Ellen M., Davis, Franklin A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2012
Aiheet:
Drug Discovery and Translational Medicine
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477221/
https://ncbi.nlm.nih.gov/pubmed/22895898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.193771
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