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INTERACTION OF COCAINE-, BENZTROPINE-, AND GBR12909-LIKE COMPOUNDS WITH WILDTYPE AND MUTANT HUMAN DOPAMINE TRANSPORTERS: MOLECULAR FEATURES THAT DIFFERENTIALLY DETERMINE ANTAGONIST BINDING PROPERTIES

The widely abused psychostimulant cocaine is thought to elicit its reinforcing effects primarily via inhibition of the neuronal dopamine transporter (DAT). However, not all DAT inhibitors share cocaine’s behavioral profile, despite similar or greater affinity for the DAT. This may be due to differen...

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Bibliografske podrobnosti
Main Authors:	Schmitt, Kyle C., Zhen, Juan, Kharkar, Prashant, Mishra, Manoj, Chen, Nianhang, Dutta, Aloke K., Reith, Maarten E.A.
Format:	Artigo
Jezik:	Inglês
Izdano:	2008
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2728472/ https://ncbi.nlm.nih.gov/pubmed/18786172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05667.x
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INTERACTION OF COCAINE-, BENZTROPINE-, AND GBR12909-LIKE COMPOUNDS WITH WILDTYPE AND MUTANT HUMAN DOPAMINE TRANSPORTERS: MOLECULAR FEATURES THAT DIFFERENTIALLY DETERMINE ANTAGONIST BINDING PROPERTIES

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