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Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: Binding characterization at D2/D3 receptors and elucidation of a pharmacophore model

A series of structurally constrained analogues based on hybrid compounds containing octahydrobenzo[g or f]quinoline moieties were designed, synthesized and characterized for their binding to dopamine D2 and D3 receptors expressed in HEK-293 cells. Among the newly developed constrained molecules, tra...

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Detalhes bibliográficos
Main Authors: Brown, Dennis A., Kharkar, Prashant S., Parrington, Ingrid, Reith, Maarten E.A., Dutta, Aloke K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607046/
https://ncbi.nlm.nih.gov/pubmed/19053758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8008629
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