A carregar...
Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: Impact on functional activity and selectivity for dopamine D2/D3 receptors
The goal of the present study was to explore, in our previously developed hybrid template, the effect of introduction of additional heterocyclic rings (mimicking catechol hydroxyl groups as bioisosteric replacement) on selectivity and affinity for the D(3) versus D(2) receptor. In addition, we wante...
Na minha lista:
| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760392/ https://ncbi.nlm.nih.gov/pubmed/23623679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.059 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|