Investigation of various N-heterocyclic substituted piperazine versions of 5/ 7-{[2-(4-Aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: Effect on affinity and selectivity for dopamine D3 receptor

Here we report on the design and synthesis of several heterocyclic analogues belonging to the 5/ 7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol series of molecules. Compounds were subjected to [3H]spiperone binding assays, carried out with HEK-293 cells express...

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Detalhes bibliográficos
Main Authors: Brown, Dennis A., Mishra, Manoj, Zhang, Suhong, Biswas, Swati, Parrington, Ingrid, Antonio, Tamara, Reith, Maarten E. A., Dutta, Aloke K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701157/
https://ncbi.nlm.nih.gov/pubmed/19427222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.04.031
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