Novel C-1 Substituted Cocaine Analogs Unlike Cocaine or Benztropine

Despite a wealth of information on cocaine-like compounds, there is no information on cocaine analogs with substitutions at C-1. Here, we report on (R)-(−)-cocaine analogs with various C-1 substituents: methyl (2), ethyl (3), n-propyl (4), n-pentyl (5), and phenyl (6). Analog 2 was equipotent to coc...

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Bibliographic Details
Main Authors: Reith, Maarten E. A., Ali, Solav, Hashim, Audrey, Sheikh, Imran S., Theddu, Naresh, Gaddiraju, Narendra V., Mehrotra, Suneet, Schmitt, Kyle C., Murray, Thomas F., Sershen, Henry, Unterwald, Ellen M., Davis, Franklin A.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477221/
https://ncbi.nlm.nih.gov/pubmed/22895898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.193771
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