Novel C-1 Substituted Cocaine Analogs Unlike Cocaine or Benztropine

Despite a wealth of information on cocaine-like compounds, there is no information on cocaine analogs with substitutions at C-1. Here, we report on (R)-(−)-cocaine analogs with various C-1 substituents: methyl (2), ethyl (3), n-propyl (4), n-pentyl (5), and phenyl (6). Analog 2 was equipotent to coc...

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Detalhes bibliográficos
Main Authors: Reith, Maarten E. A., Ali, Solav, Hashim, Audrey, Sheikh, Imran S., Theddu, Naresh, Gaddiraju, Narendra V., Mehrotra, Suneet, Schmitt, Kyle C., Murray, Thomas F., Sershen, Henry, Unterwald, Ellen M., Davis, Franklin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477221/
https://ncbi.nlm.nih.gov/pubmed/22895898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.193771
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