Novel C-1 Substituted Cocaine Analogs Unlike Cocaine or Benztropine

Despite a wealth of information on cocaine-like compounds, there is no information on cocaine analogs with substitutions at C-1. Here, we report on (R)-(−)-cocaine analogs with various C-1 substituents: methyl (2), ethyl (3), n-propyl (4), n-pentyl (5), and phenyl (6). Analog 2 was equipotent to coc...

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Autors principals: Reith, Maarten E. A., Ali, Solav, Hashim, Audrey, Sheikh, Imran S., Theddu, Naresh, Gaddiraju, Narendra V., Mehrotra, Suneet, Schmitt, Kyle C., Murray, Thomas F., Sershen, Henry, Unterwald, Ellen M., Davis, Franklin A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2012
Matèries:
Drug Discovery and Translational Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477221/
https://ncbi.nlm.nih.gov/pubmed/22895898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.193771
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